La Habana, Cuba. Se tomaron muestras de suero al momento del nacimiento y a las 72 horas siguientes. Resultados: todos los pacientes presentaron valores elevados en suero, de los tres analitos, a las 24 y 72 horas de nacidos. Serum determinations of neuron-specific enolase, lactate dehydrogenase, and aspartate aminotransferase have been used as markers of perinatal asphyxia.
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La Habana, Cuba. Se tomaron muestras de suero al momento del nacimiento y a las 72 horas siguientes. Resultados: todos los pacientes presentaron valores elevados en suero, de los tres analitos, a las 24 y 72 horas de nacidos.
Serum determinations of neuron-specific enolase, lactate dehydrogenase, and aspartate aminotransferase have been used as markers of perinatal asphyxia. Objectives: evaluate the value of serum determinations of lactate dehydrogenase, aspartate aminotransferase and neuron-specific enolase as molecular markers of perinatal asphyxia. Serum samples were taken at birth and 72 hours later.
Lactate dehydrogenase and aspartate aminotransferase were quantified by espectrophotometry. Results: all the patients had high serum values of the three analytes 24 and 72 hours after birth. Enzyme values did not vary significantly from 24 to 72 hours after birth, not considering the grade of hypoxic-ischemic encephalopathy.
A positive correlation was found between enzyme values for neuron-specific enolase and lactate dehydrogenase at 24 and 72 hours. It was not possible to differentiate the grade of hypoxic-ischemic encephalopathy via the serum levels of these enzymes. Conclusions: the values of these enzyme determinations contribute to describe the status of neonates with perinatal asphyxia from a biochemical point of view. Key words: perinatal asphyxia; hypoxic-ischemic encephalopathy; neuron-specific enolase; lactate dehydrogenase; aspartate aminotransferase.
Los resultados de los pacientes se obtienen y se leen entonces de la curva. Los valores de ASAT se correlacionaron al evaluar a las 24 y 72 horas. Esto hace que se eleven las concentraciones de lactato y se active la LDH. Early neonatal deaths with perinatal asphyxia in very low birth weight Brazilian infants. J Perinatol. Perinatal asphyxia: a review from a metabolomics perspective.
Adv Exp Med Biol. Serum enzyme activities in full-term asphyxiated and healthy newborns: enzyme kinetics during the first hours of life.
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Can biochemical markers predict the severity of hypoxic-ischemic encephalopathy? Turk J Pediatr. Changes in laboratory parameters indicating cell necrosis and organ dysfunction in asphyxiated neonates on moderate systemic hypothermia.
Acta Paediatr. Salivary lactate dehydrogenase levels can provide early diagnosis of hypoxic-ischaemic encephalopathy in neonates with birth asphyxia. Serum liver enzyme pattern in birth asphyxia associated liver injury. Pediatr Gastroenterol Hepatol Nutr. Lactate dehydrogenase in hypothermia-treated newborn infants with hypoxic-ischaemic encephalopathy. Lactate dehydrogenase predicts hypoxic ischaemic encephalopathy in newborn infants: a preliminary study.
Lackmann GM. Influence of neonatal idiopathic respiratory distress syndrome on serum enzyme activities in premature healthy and asphyxiated newborns. Am J Perinatol. Cardiac markers in the pericardial fluid in sudden coronary death. Klin Lab Diagn. Biochemical parameters predictive of neuronal damage in childhood. Rev Neurol.
Recibido: 24 de julio de Aprobado: 4 de septiembre de
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